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As the authors stated, To our knowledge this is the first lifestyle intervention study where remission of T2D has been studied with 100% remission with a feeding study using meals and food obtained from local grocery stores. However, unlike GLP-1 drugs, a calorie-restricted diet with the same macronutrient composition as the Zone diet causes weight loss without loss of lean body mass in both individuals with type 2 diabetes (7) as well as those with pre-diabetes (8)

Metabolic effects like improved insulin sensitivity fade as medication clears

Common side effects of orlistat : Oily or fatty stools, frequent bowel movements, and abdominal discomfort

9 Should You Wait for Oral Options

10.1038/s41589-019-0277-7 Nat